Instruct patients to swallow MORPHABOND ER tablets full; crushing, chewing, or dissolving MORPHABOND ER tablets may cause immediate launch and absorption of the likely lethal dose of morphine.
If adrenal insufficiency is diagnosed, handle with physiologic alternative doses of corticosteroids. Wean the patient off of the opioid to allow adrenal operate to recover and continue on corticosteroid procedure until finally adrenal operate recovers. Other opioids might be tried as some conditions claimed use of a special opioid with no recurrence of adrenal insufficiency. The knowledge readily available does not identify any specific opioids as becoming much more prone to be linked to adrenal insufficiency.
Watch patients using a heritage of seizure disorders for worsened seizure Handle during MORPHABOND ER therapy.
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If opioid use is necessary for a protracted period within a pregnant lady, suggest the affected individual of the risk of neonatal opioid withdrawal syndrome and be certain that appropriate therapy is going to be readily available.
Because extended-launch solutions for example MORPHABOND ER provide the opioid more than useful reference an prolonged timeframe, There exists a greater hazard for overdose and Demise as a result of larger amount of morphine existing.
MORPHABOND ER may possibly impair the mental or Actual physical skills needed to perform possibly hazardous actions like driving an automobile or working machinery.
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If an opioid analgesic is initiated in a very affected person by now taking a benzodiazepine or other CNS depressant, prescribe a lower initial dose on the opioid analgesic, and titrate according to medical reaction. Follow sufferers carefully for signs and indicators of respiratory despair and sedation.
MORPHABOND ER is contraindicated in sufferers with gastrointestinal obstruction, including paralytic ileus.
In sufferers who may be vulnerable to the intracranial consequences of CO2 retention (eg, These with proof of amplified intracranial pressure or brain tumors), MORPHABOND ER may well reduce respiratory generate, plus go to my site the resultant CO2 retention can further more improve intracranial stress.
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MORPHABOND™ ER exposes sufferers together with other customers for the risks of opioid habit, abuse, and misuse, which can result in overdose and death. Evaluate Just about every individual’s risk previous to prescribing MORPHABOND ER, and keep an eye look at these guys on all sufferers often for the development of such behaviors or problems.
Due to these threats, reserve concomitant prescribing of those prescription drugs for use in people for whom substitute procedure possibilities are insufficient.
Reserve concomitant prescribing of MORPHABOND ER and benzodiazepines or other CNS depressants for use in sufferers for whom alternate therapy possibilities are insufficient
Keep track of these patients for indications of hypotension immediately after initiating or titrating the dosage of MORPHABOND ER. In people with circulatory shock, MORPHABOND ER may perhaps induce vasodilation which will further reduce cardiac output and hypertension. Stay clear of the usage of MORPHABOND ER in individuals with circulatory shock.